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Inne
In search of new anticancer drug : dimethylsulfoxide ruthenium(III) complex with bulky triazolopyrimidine derivative and preliminary studies towards understanding the mode of action.
Autorzy
Rok wydania
2018
Czasopismo
Numer woluminu
141
Strony
239-246
DOI
10.1016/j.poly.2017.11.035
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
By reacting of [H(dmso)2]trans-[RuCl4(dmso)2] with 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp) in molar ratio of M:L = 1:2 new ruthenium(III) complex mer,cis-[RuCl3(dbtp)2(dmso)] has been prepared and structurally characterized by X-ray, IR and EPR spectroscopies. The crystal structure of the Ru(III) complex showed slightly distorted octahedral geometry with unique cis positioned monodentate dbtp ligands bound to the ruthenium(III) ion through the N3 nitrogen atom. In vitro toxicity assay proves that slightly lipophilic the mer,cis-[RuCl3(dbtp)2(dmso)] (log P = 0.80) is 5-fold less toxic against non-tumorigenic human epithelial cell line (MCF-10A) and normal murine embryonic fibroblast cells (BALB/3T3) than cisplatin. Preliminary studies towards understanding the mode of action suggested that activation by reduction, electrostatic interactions of the mer,cis-[RuCl3(dbtp)2(dmso)] with CT-DNA and selective delivery to cells by apotransferrin might be relevant for the biological properties of the complex.
Słowa kluczowe
Ruthenium(III) complex, Triazolopyrimidine, In vitro cytoxicity, CT-DNA, Proteins
Adres publiczny
http://dx.doi.org/10.1016/j.poly.2017.11.035
Strona internetowa wydawcy
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