Wydział Chemii

Marzena Fandzloch

Andrzej Wojtczak

Joanna Wiśniewska

Krystian Stefańczak

Juan Manuel Salas

Iwona Łakomska

2016

Inorganica Chimica Acta

443

170-178

10.1016/j.ica.2015.12.036

Naukowa

Angielski

Artykuł

X-ray structures of two Ru(III) complexes of the “Keppler-type”, [(CH₃)₂NH₂]trans-[RuCl₄(HmtpO)₂] (1a) and [H₂mtpO]trans-[RuCl₄(HmtpO)₂]·3H₂O (1b), have been determined. The structures of both compounds established two monodentate heterocycle ligands (HmtpO) via N3 in axial positions and four equatorial chloride ions. The complexes differ only in the counter ion, which is a protonated dimethylamine [(CH₃)₂NH₂]⁺ for (1a) and a protonated [H₂mtpO]⁺ for (1b). Additionally, (1a) was characterized by EPR spectroscopy, and the effective magnetic moment measurement supports the paramagnetic character, corresponding to the expected 4d⁵ (S = 1/2) electron configuration for a Ru(III) core. CD studies on hydrophilic (1a) (logP = −1.28) suggested Ru(III) mechanisms of biological action that involve activation by reduction (with E_red = −0.053 V versus NHE) and selective delivery by apotransferrin. Furthermore, it is suggested that the described (1a)-BSA adducts might form in vivo and might be relevant for the biological properties of this complex, and thus adducts may be tested as specific carriers of the ruthenium complex to cancer cells.

Ruthenium(III) complex, Triazolopyrimidine, X-ray, Apotransferrin, Albumin

http://dx.doi.org/10.1016/j.ica.2015.12.036

http://www.elsevier.com