Wydział Chemii

Iwona Łakomska

Marzena Fandzloch

Tadeusz Muzioł

Jerzy Sitkowski

Joanna Wietrzyk

2012

Journal of Inorganic Biochemistry

115

100-105

10.1016/j.jinorgbio.2012.05.005

Naukowa

Angielski

Artykuł

To compare the in vitro cytotoxicity of platinum(II) complexes with 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp), three complexes were prepared: cis-[PtI₂(dbtp)₂] (1), cis-[Pt(NO₃)₂(dbtp)₂] (2) and cis-[Pt(C₄H₄O₅)(dbtp)₂] (3). The coordination compounds have been structurally characterized by IR; ¹H, ¹³C, ¹⁵N, ¹⁹⁵Pt NMR and single-crystal X-ray diffraction (1). Spectroscopic studies reveal the monodentate coordination of the heterocycleligand (dbtp) via N(3) to platinum(II) ions. In addition, the crystal structure of (1) shows that the platinum(II) ion is located in nearly square-planar PtI₂N₂ environments with two heterocycle ligands (dbtp) arranged in a head-to-head orientation. The complexes have been screened for their cytotoxicity against two human cells: non-small cell lung carcinoma (A549) and breast cancer (T47D). All of the complexes demonstrated a significant antiproliferative activity against both cell lines. On the basis of these results, it is concluded that the cytotoxicity of the studied compounds against T47D follows the order: (3) < (1) < (2).

Platinum(II) complex, 15N NMR, X-ray, Triazolopyrimidine, In vitro cytotoxicity

http://dx.doi.org/10.1016/j.jinorgbio.2012.05.005

http://www.elsevier.com