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Taxines from the needles ofTaxus wallichiana.
Autorzy
Rok wydania
2001
Czasopismo
Numer woluminu
58
Strony
1167-1170
DOI
10.1016/S0031-9422(01)00305-3
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A taxine, 5αO-(3′-dimethylamino-3′-phenylpropionyl) taxinine M (1) together with two known compounds 7-O-acetyltaxine A (2) and 2α-acetoxy-2′β-deacetylaustrospicatine (3) were isolated from the needles of the Himalayan yew, Taxus wallichiana Zucc. Their structures were elucidated on the basis of the NMR spectral data, ESI–MS/MS analysis and chemical methods. Compounds 1 and 3 showed moderate cytotoxic activity against the lung cancer cell line A549 in vitro.A cytotoxic taxine, 5α-O-(3′dimethylamino-3′phenylpropionyl)taxamine M (1) was isolated from the needles of Taxus wallichiana. Its structure was elucidated by analysis of its ESI–MS tandem mass and 2D NMR spectral analyses.
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