Repozytorium
Wyszukaj
Kolekcje
Inne
Detection and partial structure elucidation of basic taxoids from Taxus wallichiana by electrospray lonization tandem mass spectrometry.
Autorzy
Rok wydania
2001
Czasopismo
Numer woluminu
73
Strony
3583-3589
DOI
10.1021/ac010254i
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A sensitive method for the detection and characterization of basic taxoids from the ethyl acetate extract of Taxus wallichiana has been described. A combined analysis of the fragmentation spectra of 3 purified standard basic taxoids and the substructure analysis of 139 previously reported taxoids provided information on typical primary and secondary product ions that are generated by CID mass spectrometry of basic taxoids. Precursor-scan analysis of selected product ions allowed for the detection of 57 basic taxoids from the ethyl acetate extract of T. wallichiana, 45 of which have not been reported. The method describe in this paper provides a fast method for the “dereplication” of natural products. The mass spectrometric data derived by this method was sufficient for the partial structure elucidation of novel basic taxoids. The method presented in this paper can be easily adapted into a high-throughput screening protocol for the identification and characterization of bioactive natural products.
Słowa kluczowe
Fragmentation, Ions, Mass spectrometry, Organic compounds, Scaffolds
Adres publiczny
https://doi.org/10.1021/ac010254i
Strona internetowa wydawcy
Podobne publikacje
Interactions of anti-Parkinson drug benserazide with Zn(II), Cu(II), Fe(II) ions.
Szyrwiel Łukasz, Pap József Sándor, Malinka Wiesław, Szewczuk Zbigniew, Kotynia Aleksandra, Brasuń Justyna
ESI-MS study of ionization pathways and cation-receptor properties of the iron(II) mono- and bis-clathrochelates.
Varzatskii Oleg A., Shul'ga Sergey V., Kozłowski Henryk, Gumienna-Kontecka Elżbieta, Szyrwiel Łukasz, Lebed Ekaterina G., Voloshin Yan Z.
Detection of glycation sites in proteins by high-resolution mass spectrometry combined with isotopic labeling.
Stefanowicz Piotr, Kijewska Monika, Kluczyk Alicja, Szewczuk Zbigniew