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Impact of metal coordination and pH on the antimicrobial activity of histatin 5 and the products of its hydrolysis
Autorzy
Rok wydania
2024
Czasopismo
Numer woluminu
53
Strony
7561-7570
DOI
10.1039/d4dt00565a
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
This work focuses on the relationship between the coordination chemistry and antimicrobial activity of Zn(II) and Cu(II) complexes of histatin 5 and the products of its hydrolysis: its N-terminal fragment (histatin 5–8) and C-terminal fragment (histatin 8). Cu(II) coordinates in an albumin-like binding mode and Zn(II) binds to up to 3 His imidazoles. The antimicrobial activity of histatins and their metal complexes (i) strongly depends on pH – they are more active at pH 5.4 than at 7.4; (ii) the complexes and ligands alone are more effective in eradicating Gram-positive bacteria than the Gram-negative ones, and (iii) Zn(II) coordination is able to change the structure of the N-terminal region of histatin 5 (histatin 5–8) and moderately increase all of the studied histatins’ antimicrobial potency.
Adres publiczny
http://dx.doi.org/10.1039/D4DT00565A
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