Repozytorium
Wyszukaj
Kolekcje
Inne
Novel perspective on Alzheimer’s disease treatment: rosmarinic acid molecular interplay with copper(II) and amyloid β.
Autorzy
Rok wydania
2020
Czasopismo
Numer woluminu
10
Strony
118/1-118/18
DOI
10.3390/life10070118
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Alzheimer’s disease is a severe disorder that affects millions of people worldwide. It is a very debilitating disease with no cure at the moment. The necessity of finding an effective treatment is very demanding, and the entire scientific community is putting in a lot of effort to address this issue. The major hallmark of Alzheimer’s disease is the presence of toxic aggregated species in the brain, impaired metal homeostasis, and high levels of oxidative stress. Rosmarinic acid is a well-known potent antioxidant molecule, the efficacy of which has been proved both in vitro and in vivo. In this study, we investigated the possible role played by rosmarinic acid as a mediator of the copper(II)-induced neurotoxicity. Several spectroscopic techniques and biological assays were applied to characterize the metal complexes and to evaluate the cytotoxicity and the mutagenicity of rosmarinic acid and its Cu(II) complex. Our data indicate that rosmarinic acid is able to interfere with the interaction between amyloid β and Cu(II) by forming an original ternary association.
Słowa kluczowe
amyloid ß, copper, rosmarinic acid, Antioxidant, polyphenols
Licencja otwartego dostępu
Licencja na prawach której można swobodnie kopiować, rozprowadzać, zmieniać i remiksować objęty prawem autorskim utwór (Utwór-przedmiot prawa autorskiego) pod warunkiem podania imienia i nazwiska autora utworu pierwotnego oraz źródła pochodzenia utworu.
Pełny tekst licencji: https://creativecommons.org/licenses/by/3.0/pl/legalcode
Adres publiczny
http://dx.doi.org/10.3390/life10070118
Strona internetowa wydawcy
Podobne publikacje
The role of the βAsp residue in copper(II) binding by modified peptides.
Czapor-Irzabek Hanna, Cebrat Marek, Brasuń Justyna
NMR metabolomic investigation of astrocytes interacted with Aβ42 or its complexes with either copper(II) or zinc(II).
Rocchi Altea, Valensin Daniela, Aldinucci Carlo, Giani Gabriele, Barbucci Rolando, Gaggelli Elena, Kozłowski Henryk, Valensin Gianni
Determination of antioxidant activity and polyphenols content in chips by Raman and IR spectroscopy.
Mazurek Sylwester, Szostak Roman, Kita Agnieszka, Kucharska Alicja Z., Sokół-Łętowska Anna, Hamouz Karel