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Inne
Anesthetic-dependent changes in the chain-melting phase transition of DPPG liposomes studied using near-infrared spectroscopy supported by PCA.
Autorzy
Rok wydania
2017
Czasopismo
Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
Numer woluminu
186
Strony
37-43
DOI
10.1016/j.saa.2017.06.003
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The effect of inhalation anesthetics (enflurane, isoflurane, sevoflurane or halothane) on the lipid chain-melting phase transition of negatively charged phospholipid membranes was studied using near-infrared (NIR) spectroscopy supported by Principal Component Analysis (PCA). NIR spectra of anesthetics-mixed dipalmitoylphosphatidylglycerol (DPPG) membranes were recorded in a range of the first overtone of the symmetric and antisymmetric stretching vibrations of CH2 groups of lipid aliphatic chains as a function of increasing temperature. Anesthetic-dependent changes in the trans to gauche conformers ratio of CH2 groups in the hydrocarbon lipid chains were characterized in detail and compared with the zwitterionic lipid membranes, which were built of dipalmitoylphosphatidylcholine (DPPC) molecules.
Słowa kluczowe
Charged lipid membranes, trans to gauche isomerization, Near-infrared spectroscopy (NIR), principal component analysis (PCA), mechanism of anesthesia
Adres publiczny
http://dx.doi.org/10.1016/j.saa.2017.06.003
Strona internetowa wydawcy
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