Repozytorium
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Kolekcje
Inne
NIR studies of cholesterol-dependent structural modification of the model lipid bilayer doped with inhalation anesthetics.
Autorzy
Rok wydania
2018
Czasopismo
Journal of Molecular Structure
Numer woluminu
1162
Strony
17-25
DOI
10.1016/j.molstruc.2018.02.086
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The influence of cholesterol on the structure of the model lipid bilayers treated with inhalation anesthetics (enflurane, isoflurane, sevoflurane and halothane) was investigated employing near-infrared (NIR) spectroscopy combined with the Principal Component Analysis (PCA). The conformational changes occurring in the hydrophobic area of the lipid bilayers were analyzed using the first overtones of symmetric (2νs) and antisymmetric (2νas) stretching vibrations of the CH2 groups of lipid aliphatic chains. The temperature values of chain-melting phase transition (Tm) of anesthetic-mixed dipalmitoylphosphatidylcholine (DPPC)/cholesterol and dipalmitoylphosphatidylglycerol (DPPG)/cholesterol membranes, which were obtained from the PCA analysis, were compared with cholesterol-free DPPC and DPPG bilayers mixed with inhalation anesthetics.
Słowa kluczowe
Cholesterol, Anesthetics, Phospholipids, phase transition, Near-infrared spectroscopy (NIR), principal component analysis (PCA)
Adres publiczny
https://doi.org/10.1016/j.molstruc.2018.02.086
Strona internetowa wydawcy
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