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Inne
β-aryl-δ-hydroxy-γ-lactones: synthesis, structural analysis and cytotoxic activity.
Autorzy
Rok wydania
2016
Czasopismo
Numer woluminu
13
Strony
901-906
DOI
10.2174/1570179413666151218201553
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
A series of epoxyesters were lactonized by HClO4 to give corresponding ς-hydroxy-γ-lactones as a mixture of diastereoisomers: trans and cis. The mixtures of products were separated via column chromatography. The lactones synthesized were screened for anticancer activity against D17 and U2-OS cell lines. Only the trans isomer with naphthyl ring was found to exhibit significant activity against both cell lines.
Słowa kluczowe
Lactones, epoxyester, aromatic ring, diastereoisomers, hydroxlactonization, antiproliferative activity
Adres publiczny
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