Repozytorium
Wyszukaj
Kolekcje
Inne
Hydroxy lactones with the gem-dimethylcyclohexane system : synthesis and antimicrobial activity.
Autorzy
Rok wydania
2019
Czasopismo
Numer woluminu
12
Strony
2280-2288
DOI
10.1016/j.arabjc.2015.02.018
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Two new lactones comprising the gem-dimethylcyclohexane ring: 2-chloro-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one and 2-bromo-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one as well as the already known 2-iodo-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one, were obtained from (6,6-dimethylcyclohex-2-en-1-yl)acetic acid. These lactones were used as substrates for the screening of biotransformation by whole cells of nine fungal strains (Fusarium species, Syncephalastrum racemosum and Cunninghamella japonica). Some of these microorganisms (mainly Fusarium species) transformed all three lactones during the hydrolytic dehalogenation into 2-hydroxy-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one. It is worth noting that two microorganisms (Fusarium culmorum and Fusarium scirpi) converted iodolactone with very high enantioselectivity (75.1% and 91.6%, respectively). The (+) isomer of hydroxy lactone was preferred. At the last step the hydroxy lactone obtained during biotransformation was examined for its biological activity against bacteria, yeasts and fungi. It was found that this compound inhibits growth of some tested microorganisms.
Słowa kluczowe
lactones, biotransformations, Hydrolytic dehalogenation, Fusarium species, antimicrobial activity
Licencja otwartego dostępu
Licencja ta zezwala na rozpowszechnianie, przedstawianie i wykonywanie utworu jedynie w celach niekomercyjnych oraz pod warunkiem zachowania go w oryginalnej postaci (nie tworzenia utworów zależnych). Jest to najbardziej restrykcyjna z licencji.
Pełny tekst licencji: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
Adres publiczny
http://dx.doi.org/10.1016/j.arabjc.2015.02.018
Strona internetowa wydawcy
Podobne publikacje
Biotransformations of bicyclic trimethylcyclohexane chloro-, bromo- and iodolactones using fungal strains.
Grabarczyk M., Białońska Agata
New Hydroxylactones and Chloro-Hydroxylactones Obtained by Biotransformation of Bicyclic Halolactones and Their Antibacterial Activity
Grabarczyk Małgorzata, Duda-Madej Anna, Romanenko Fedor, Maciejewska Gabriela, Mączka Wanda, Białońska Agata, Wińska Katarzyna
Fungistatic activity of bicyclo[4.3.0]-γ-lactones.
Olejniczak Teresa, Boratyński Filip, Białońska Agata