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Inne
New chiral Mannich adducts of di-tert-butylphenols and a bicyclic imine : synthesis and antiproliferative activity.
Autorzy
Rok wydania
2017
Czasopismo
Numer woluminu
73
Strony
2276-2282
DOI
10.1016/j.tet.2017.03.017
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Tests of antiproliferative activity of Mannich adducts of aromatic nucleophiles and a chiral bicyclic imine revealed a di-tert-butylphenol derivative as a promising compound for further exploration. To study the influence of substitution pattern and a configuration of stereogenic centers on the inhibition of cancer cell growth, a series of Mannich bases were obtained with a good to high diastereoselectivity from the reaction of the imine and three isomeric di-tert-butylphenols. Six new enantiopure adducts were isolated and fully characterized. Selected derivatives were shown to exhibit an interesting antiproliferative activity comparable to cisplatin.
Słowa kluczowe
antiproliferative activity, imines, Mannich bases, Mannich reaction, Stereoselectivity
Adres publiczny
http://dx.doi.org/10.1016/j.tet.2017.03.017
Strona internetowa wydawcy
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