Repozytorium
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Kolekcje
Inne
Correlation between type of alkali rinsing, cytotoxicity of bio-nanocellulose and presence of metabolites within cellulose membranes.
Autorzy
Rok wydania
2017
Czasopismo
Numer woluminu
157
Strony
371-379
DOI
10.1016/j.carbpol.2016.10.007
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The study aimed at evaluation of various types of alkali rinsing with regard to their efficacy in terms of removal, not only of bacteria but also bacterial metabolites, from cellulose matrices formed by three Komagataeibacter xylinus strains. Moreover, we tested the type of alkali rinsing on membrane cytotoxicity in vitro in fibroblast and osteoblast cells and we compared matrices’ ability to induce oxidative stress in macrophages. We identified 11 metabolites of bacterial origin that remained in cellulose after rinsing. Moreover, our results indicated that the type of alkali rinsing should be adjusted to specific K. xylinus strains that are used as cellulose producers to obtain safe biomaterials in the context of low cytotoxicity and macrophage induction. The findings have translational importance and may be of direct significance to cellulose dressing manufacturers.
Słowa kluczowe
Alkali rinsing, Bacterial nanocellulose, Metabolite, cytotoxicity, Macrophages
Adres publiczny
http://dx.doi.org/10.1016/j.carbpol.2016.10.007
Strona internetowa wydawcy
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