Repozytorium
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Kolekcje
Inne
Application of bacterial cellulose experimental dressings saturated with gentamycin for management of bone biofilm in vitro and ex vivo.
Autorzy
Rok wydania
2020
Czasopismo
Journal of Biomedical Materials Research Part B-Applied Biomaterials
Numer woluminu
108
Strony
30-37
DOI
10.1002/jbm.b.34362
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Bacterial cellulose is one of the most promising polymers of recent years. Herein, we present a possibility of BC application as a carrier of gentamycin antibiotic for the treatment and prevention of bone infections. We have shown that BC saturated with gentamycin significantly reduces the level of biofilm‐forming bone pathogens, namely Staphylococcus aureus and Pseudomonas aeruginosa, and displays very low cytotoxicity in vitro against osteoblast cell cultures. Another beneficial feature of our prototype dressing is prolonged release of gentamycin, which provides efficient protection from microbial contamination and subsequent infection. Moreover, it seems that bacterial cellulose (BC) alone without any antimicrobial added, may serve as a barrier by significantly hampering the ability of the pathogen to penetrate to the bone structure. Therefore, a gentamycin‐saturated BC dressing may be considered as a possible alternative for gentamycin collagen sponge broadly used in clinical setting
Słowa kluczowe
bone infection, gentamycin, bacterial cellulose, biofilm
Adres publiczny
https://doi.org/10.1002/jbm.b.34362
Strona internetowa wydawcy
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