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Inne
Rhodium(III) complexes with polypyridyls and pyrazole and their antitumor activity.
Autorzy
Rok wydania
2002
Czasopismo
Numer woluminu
334
Strony
59-66
DOI
10.1016/S0020-1693(02)00776-4
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Synthesis and properties of rhodium complexes with nitrogen ligands [RhCl2(Hpz)4][RhCl4(Hpz)2] (1), [RhCl3(tpy)] (2), [RhCl3(tpta)]·H2O (3) and [Rh(tpy)2(Him)]Cl3·3H2O (4), have been described. X-ray structures of complexes 1–3 have been determined. IR, UV–Vis and 1H NMR spectra of the complexes have been discussed. Cytostatic activity of the complexes against HCV29T tumor cells increases in the series: 1<3<2<4. The cytostatic activity of complex 4 is greater than that of cisplatin. Interaction of the complexes with DNA has been investigated.The compounds [RhCl2(Hpz)4][RhCl4(Hpz)2], [RhCl3(tpy)], [RhCl3(tpta)]·H2O and [Rh(tpy)2(Him)]Cl3·3H2O have been prepared and characterized using spectroscopic methods and X-ray crystallography. The complexes are effective cytostatic agents against HCV29T tumor cells. The cytostatic activity of the last complex is greater than that of cisplatin. Interaction of the complexes with DNA has been investigated.
Słowa kluczowe
Rhodium(III) complexes, Antitumor, Cytostatic activity
Adres publiczny
https://doi.org/10.1016/S0020-1693(02)00776-4
Strona internetowa wydawcy
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