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Structure, properties and cytostatic activity of tributyltin aminoarylcarboxylates.

Autorzy

Florian P. Pruchnik

Małgorzata Bańbuła

Zbigniew Ciunik

Małgorzata Latocha

B. Skop

T. Wilczok

Rok wydania

2003

Czasopismo

Inorganica Chimica Acta

Numer woluminu

356

Strony

62-68

DOI

10.1016/S0020-1693(03)00475-4

Kolekcja

Naukowa

Język

Angielski

Typ publikacji

Artykuł

Streszczenie

Properties of butyltin complexes [Sn(C4H9-n)3{OOCC6H3(NH2)2-3,4}]n (1), [Sn(C4H9-n)3{OOCC6H3(NH2)2-3,5}] (2), [Sn(C4H9-n)3{OOCC6H4NNC6H4N(CH3)2-4}] (3) and [Sn(C6H5)3{OOCC6H3(NH2)2-3,5}]n (4) have been investigated. 1H, 13C and 119Sn NMR spectra indicate that the compounds in chloroform are distorted tetrahedral and in strongly coordinating solvents trigonal-bipyramidal complexes. Structure of complex 3 has been determined by X-ray crystallography. This compound adopts trigonal bipyramidal structure with bridging carboxylato ligand bound asymmetrically with tin atoms in axial positions. The complexes are effective cytostatic agents. Complexes [Sn(C4H9)3(OOCR)] with diaminobezoates and OOCC6H4NNC6H4N(CH3)2-4 are efficient cytostatic agents against A549 tumor cells in aqueous ethanol. Complex [Sn(C4H9)3{OOC-2-C6H4NNC6H4N(CH3)2-4}]n (3), is a zigzag single-strand polymer with carboxylate ligand coordinated as a bridging ligand. Coordination of the central atom is trigonal-bipyramidal. The crystal structure of complex 3 is stabilized by intermolecular stacking interaction between phenyl rings. The NMR spectra revealed that in chloroform solutions tetrahedral complexes 1–4 are present, however, in strongly coordinating solvent, dimethyl sulfoxide, coordination number increases and five-coordinate compounds are formed.

Słowa kluczowe

Organotin complexes, Cytostatic agents, Antitumor activity, Crystal structures

Adres publiczny

https://doi.org/10.1016/S0020-1693(03)00475-4

Strona internetowa wydawcy

http://www.elsevier.com

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