Repozytorium
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Kolekcje
Inne
Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation).
Autorzy
Rok wydania
2009
Czasopismo
Coordination Chemistry Reviews
Numer woluminu
253
Strony
2665-2685
DOI
10.1016/j.ccr.2009.05.011
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Metal ions, especially with high chemical activity (e.g. redox-active Cu and Fe) must be carefully managed in biological systems. The “uncontrolled” activity, e.g. catalysis of Fenton-like reactions by ions like Cu(I) or Fe(II), is so damaging for the biological milieu that right from their entry, metal ions need to be strictly controlled until they arrive at their storage site. This chaperoning occurs usually by proteins which are involved in transport, delivery and distribution processes. In this review some aspects of the metal homeostasis for major metal ions (Cu, Fe, and Zn) are presented. The impact of these metals on some disorders are also discussed.
Słowa kluczowe
Copper, Iron, Zinc, Metal homeostasis, Metal transport, Regulation of metals, Diseases affected by metals
Adres publiczny
https://doi.org/10.1016/j.ccr.2009.05.011
Strona internetowa wydawcy
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