Repozytorium
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Kolekcje
Inne
Chemical structure of phenothiazines and their biological activity.
Autorzy
Rok wydania
2012
Czasopismo
Numer woluminu
64
Strony
16-23
DOI
10.1016/S1734-1140(12)70726-0
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Phenothiazines belong to the oldest, synthetic antipsychotic drugs, which do not have their precursor in the world of natural com-pounds. Apart from their fundamental neuroleptic action connected with the dopaminergic receptors blockade, phenothiazine de-rivatives also exert diverse biological activities, which account for their cancer chemopreventive-effect, as: calmodulin- and proteinkinase C inhibitory-actions, anti-proliferative effect, inhibition of P-glycoprotein transport function and reversion of multidrug re-sistance. According to literature data on relations between chemical structure of phenothiazines and their biological effects, the maindirections for further chemical modifications have been established. They are provided and discussed in this review paper
Słowa kluczowe
phenothiazine derivatives, antipsychotics, calmodulin, protein kinase C, P-glycoprotein, mulidrug resistance
Adres publiczny
http://dx.doi.org/10.1016/S1734-1140(12)70726-0
Strona internetowa wydawcy
Strona internetowa wydawcy
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