Wydział Chemii

Iwona Łakomska

Krystian Stefańczak

Marzena Fandzloch

Jerzy Sitkowski

Beata Filip-Psurska

Andrzej Wojtczak

2016

Polyhedron

109

33-39

10.1016/j.poly.2016.01.038

Naukowa

Angielski

Artykuł

A series of neutral half-sandwich organometallic ruthenium(II) complexes of the general formula [(η⁶-p-cym)Ru(L)Cl₂], where η⁶-p-cym – p-cymene, was prepared by the direct reaction of a dichloride p-cymene ruthenium(II) dimer, [{(η⁶-p-cym)Ru(μ-Cl)}₂Cl₂], with corresponding 1,2,4-triazolo[1,5-a]pyrimidine ligands (L), namely, L-1,2,4-triazolo[1,5-a]pyrimidine (tp) (1), 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (dmtp) (2), 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp) (3), 7-isobutyl-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine (ibmtp) (4), and 5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine (dptp) (5). The complexes were prepared in molar ratios of 1:2 (except (1), for which an excess of tp was used). The structures of the complexes were determined by multinuclear magnetic resonance (¹H, ¹³C, ¹⁵N) spectroscopy and X-ray diffraction. According to all the spectroscopic data, the molecules adopted the usual “piano-stool” geometry with a monodentate N3 triazolopyrimidine ligand. Studies on these lipophilic ruthenium(II) complexes revealed rather low in vitro antiproliferative activities against two human cell lines.

Ruthenium(II) complex, Triazolopyrimidine, p-Cymene, X-ray, NMR

http://dx.doi.org/10.1016/j.poly.2016.01.038

http://www.elsevier.com