Wydział Chemii

Anna Majewska

Witold Lasek

Mariola Kuczer

Grażyna Młynarczyk

2016

International Journal of Peptide Research and Therapeutics

22

255-261

10.1007/s10989-015-9506-4

Naukowa

Angielski

Artykuł

Over the past two decades there has been intense study of compounds from vertebrates, microor-
ganisms, plants, mushrooms, marine sponges, worms, etc. as well as insects in terms of their antiviral activity. Insects
produce a variety of biologically active peptides. One of them is alloferon. The in vitro and in vivo experiments
demonstrate that synthetic alloferon has an immunomod-ulatory properties. It was reported that alloferon and its
analogues (alloferon I and II) have antimicrobial properties, as well. The aim of this study was to evaluate in vitro
the effect of alloferon I and II, either alone or in combination with human lymphocytes, on human herpesvirus
type 1 (HHV-1) McIntyre strain replication. On the base of results we can conclude that alloferon I and II inhibit the
replication of HHV-1 McIntyre strain in HEp-2 cells. Enhanced antiviral activity was observed when infected
cells were treated with alloferons and unstimulated or phytohemagglutinin PHA-stimulated lymphocytes simul-
taneously. After application of alloferons and PHA-stimulated lymphocytes to the HHV-1 infected HEp-2 culture,
the mean HHV-1 titer reduction for alloferon and II, when used at the highest dose—400µgmL, were 3.69 and 3.27log10/TCID50/mL,
respectively.

alloferon, antiviral activity, Herpesvirus, HHV-1, Insect peptides, Virus replication

http://dx.doi.org/10.1007/s10989-015-9506-4

http://link.springer.com