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New alloferon analogues : synthesis and antiviral properties.
Autorzy
Rok wydania
2013
Czasopismo
Chemical Biology and Drug Design
Numer woluminu
81
Strony
302-309
DOI
10.1111/cbdd.12020
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
We have extended our study on structure/activity relationship studies of insect peptide alloferon (H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH) by evaluating the antiviral effects of new alloferon analogues. We synthesized 18 alloferon analogues: 12 peptides with sequences shortened from N- or C-terminus and 6 N-terminally modified analogues H-X(1)-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH, where X(1) = Phe (13), Tyr (14), Trp (15), Phg (16), Phe(p-Cl) (17), and Phe(p-OMe) (18). We found that most of the evaluated peptides inhibit the replication of Human Herpesviruses or Coxsackievirus B2 in Vero, HEp-2 and LLC-MK(2) cells. Our results indicate that the compound [3-13]-alloferon (1) exhibits the strongest antiviral activity (IC(50) = 38 μM) among the analyzed compound. Moreover, no cytotoxic activity against the investigated cell lines was observed for all studied peptides at concentration 165 μM or higher.
Słowa kluczowe
alloferon, antiviral activity, Insect peptides
Adres publiczny
http://dx.doi.org/10.1111/cbdd.12020
Strona internetowa wydawcy
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