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Fungistatic activity of bicyclo[4.3.0]-γ-lactones.
Autorzy
Rok wydania
2011
Czasopismo
Journal of Agricultural and Food Chemistry
Numer woluminu
59
Strony
6071-6081
DOI
10.1021/jf105019u
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Five optically active and sixteen racemic lactones (nine of them new) of bicyclo[4.3.0]nonane structure were synthesized. IC50 values for the following phytopathogens were determined: Aspergillus ochraceus AM 456, Fusarium culmorum AM 282, Fusarium oxysporum AM 13, Fusarium tricinctum AM 16. Effect of compound structures, especially stereogenic centers, on fungistatic activity has been discussed. The highest fungistatic activity was observed for trans-7,8-dibromo-cis-3-oxabicyclo[4.3.0]nonan-2-one (3c), IC50 = 30.1 μg/mL (0.10 μM/mL), and cis-7,8-epoxy-cis-3-oxabicyclo[4.3.0]nonan-2-one (3b), IC50 = 72.2 μg/mL (0.47 μM/mL), toward F. oxysporum AM 13.
Słowa kluczowe
Lactones, IC50, HLADH, Fusarium oxysporum, Fusarium culmorum
Adres publiczny
https://doi.org/10.1021/jf105019u
Strona internetowa wydawcy
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