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Inne
Interactions of anti-Parkinson drug benserazide with Zn(II), Cu(II), Fe(II) ions.
Autorzy
Rok wydania
2013
Czasopismo
Journal of Pharmaceutical and Biomedical Analysis
Numer woluminu
76
Strony
36-43
DOI
10.1016/j.jpba.2012.11.032
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
One of the treatments of Parkinson disease is based on increasing the brain dopamine level by L-DOPA (LD) applications. To prevent the peripheral degradation of levodopa, another drug, benserazide is applied. On the other hand, during this neurodegenerative disease changes in the homeostasis of metals are observed and the increasing brain zinc levels are postulated to have therapeutic effects. Here we present studies on interactions of Zn(II), Cu(II), Fe(II) ions with benserazide and with benserazide/levodopa in ternary system. By applying mass spectrometry and UV–vis methods we describe the interactions between selected metal ions and the drug additives in the investigated systems. The results show forming of equimolar complexes in the binary and ternary systems.
Słowa kluczowe
Interactions with metal ions, Stability, Benserazide, Mass spectrometry, Parkinson's disease
Adres publiczny
http://dx.doi.org/10.1016/j.jpba.2012.11.032
Strona internetowa wydawcy
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