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Inne
Binding ability of impromidine, a potent H2 agonist of histamine.
Autorzy
Rok wydania
1999
Czasopismo
Journal de Chimie Physique et de Physico-Chimie Biologique
Numer woluminu
96
Strony
1356-1366
DOI
10.1051/jcp:1999215
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Impromidine (fig.1) is a potent and selective histamine H2 receptor agonist and its structure comprises a strongly basic guanidine group containing two different imidazole-containing side chains. The present work deals with the study of coordination equilibria between impromidine and Cu(II) and Ni(II) in aqueous solution at 25 ○C. Potentiometric, UV-Visible and EPR studies on Cu(II) complexes with impromidine have shown that this anti-ulcerogenic drug is a very potent chelating agent. This drug is found to be a very effective ligand for Ni(II) ions also. The effective coordination of impromidine to metal ions may have significant biological implications.
Słowa kluczowe
Impromidine, Metal complexes, Stability constants, Potentiometry, Spectroscopy
Adres publiczny
https://doi.org/10.1051/jcp:1999215
Strona internetowa wydawcy
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