Wydział Chemii

Marzena Fandzloch

Weronika Bodylska

Adam W. Augustyniak

Katarzyna Roszek

Anna Jaromin

Anna Lukowiak

2023

Ceramics International

49

7438-7451

10.1016/j.ceramint.2022.10.225

Naukowa

Angielski

Artykuł

A binary and ternary system of highly bioactive nanoparticles of xerogel (88SiO₂–12CaO (wt.%), solvXG88, 78SiO₂–16CaO–6P₂O₅, solvXG78P6) and glass (69SiO₂–25CaO–6P₂O_5, solvBG69P6) were prepared following an unconventional solvothermal path of the synthesis. These nanosized (<50 nm), non-spherical in shape and mesoporous materials with different compositions greatly enhanced the formation process of hydroxyapatite (HA) in simulated physiological fluids compared to reference 45S5 glass, commonly used in orthopedics and dentistry. The deposition of a HA layer on the glasses was analyzed by various techniques, namely XRD, IR-ATR, ³¹P CP-MAS NMR, EDS analyses, SEM, and HR-TEM imaging. For both types of nanoparticles (glass and obtained at lower temperature xerogels) superior apatite-mineralization ability in time as short as 4 h in the physiological-like buffer was achieved thus, exceeded the bioactivity of the 45S5 glass. This unique bioactivity was complemented by biocompatibility with human dermal fibroblasts and MC3T3 mouse osteoblast precursors, verified in a wide range of concentrations, as well as hemocompatibility studies. The most promising candidate which can compete with clinically used Bioglass is solvXG78P6.

Nanoglass, Xerogel, Bioactivity, Biocompatibility, Hemocompatibility, Biomaterials

http://dx.doi.org/10.1016/j.ceramint.2022.10.225

http://www.elsevier.com