Wydział Chemii

E. Jallot

J. Lao

Łukasz John

J. Soulié

P. Moretto

Jean-Marie Nedelec

2010

ACS Applied Materials and Interfaces

2

1737-1742

10.1021/am1002316

Naukowa

Angielski

Artykuł

In this work, the physicochemical reactions occurring at the surface of bioactive sol−gel derived 3D glass scaffolds via a complete PIXE characterization were studied. 3D glass foams in the SiO₂−CaO system were prepared by sol−gel route. Samples of glass scaffolds were soaked in biological fluids for periods up to 2 days. The surface changes were characterized using particle induced X-ray emission (PIXE) associated to Rutherford backscattering spectroscopy (RBS), which are efficient methods to perform quantitative chemical maps. Elemental maps of major and trace elements at the glass/biological fluids interface were obtained at the micrometer scale for every interaction time. Results revealed interconnected macropores and physicochemical reactions occurring at the surface of pores. The micro-PIXE-RBS characterization of the pores/biological fluids interface shows the glass dissolution and the rapid formation of a Ca rich layer with the presence of phosphorus that came from biological fluids. After 2 days, a calcium phosphate-rich layer containing magnesium is formed at the surface of the glass scaffolds. We demonstrate that quantities of phosphorus provided only by the biological medium have a significant impact on the development and the formation of the phosphocalcic layer.

PIXE-RBS methods, biomaterials, Bioactive glass, sol-gel

https://doi.org/10.1021/am1002316

https://www.acs.org/content/acs/en.html