Wydział Chemii

Henryk Kozłowski

Teresa Kowalik-Jankowska

Małgorzata Jeżowska-Bojczuk

2005

Coordination Chemistry Reviews

249

2323-2334

10.1016/j.ccr.2005.04.027

Naukowa

Angielski

Artykuł

The coordination ability of histidine containing peptides towards Cu²⁺ ion is discussed. The binding ability of the peptide strongly depends on the position and number of histidine residues in the peptide sequence, the vicinal amino acid residues, and in poly-histidine peptides on the distance between the His residues within the peptide chain. The imidazole nitrogen of the His residues usually act as an anchoring site and multi-histidine Cu²⁺ binding is extremely effective; this results in the stabilization of very specific peptide structures. The nitrogen atom of the N-terminal amino group may compete with imidazole to bind Cu²⁺ ion and both of them may form an effective macrochelate coordination when they are close to each other. Amino groups of aminoglycosides are basic and very efficient binding sites for Cu²⁺ ions. The metal ion coordination to aminoglycoside antibiotics may dramatically change the pharmacological effect inducing oxidative reactions. These reactions when induced in the human body may be the reason for the side-effects caused by aminoglycosidic antibiotics.

Cu2+ complexes, Histidine peptides, Aminoglycoside antibiotics, Oxidative reactions, Biological implications

https://doi.org/10.1016/j.ccr.2005.04.027

http://www.elsevier.com