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Inne
Specificity in the Cu2+ interactions with prion protein fragments and related His-rich peptides from mammals to fishes.
Autorzy
Rok wydania
2008
Czasopismo
Coordination Chemistry Reviews
Numer woluminu
252
Strony
1069-1078
DOI
10.1016/j.ccr.2007.08.006
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The prion proteins may play a critical role in copper homeostasis and the antioxidant activity in the brain. This review presents the state of art in the studies on Cu2+ prion systems. The proteins discussed are from different species from mammals to fishes. All proteins are His-rich and the research discussed clearly indicates the basic role of imidazole side chains and the adjacent amide nitrogen atoms in metal ion binding. Prions represent the family of proteins with new mode of Cu2+ binding which includes the amide nitrogen coordination. The multi-imidazole coordination is also likely and it can play a critical role in the antioxidant activity of the copper–prion complexes. The combination of the imidazole and amide nitrogen atoms to Cu2+ ions could also be relevant in histidine-rich peptide antibiotics including demegen. The impact of peptide sequence and His positions on copper binding ability is also discussed.
Słowa kluczowe
Prion proteins, Binding of Cu2+, His-rich peptides
Adres publiczny
https://doi.org/10.1016/j.ccr.2007.08.006
Strona internetowa wydawcy
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