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Platinum(IV) coordination compounds containing 5-methyl-1,2,4-triazolo[1,5-α]pyrimidin-7(4H)-one as nonleaving ligand. Molecular and cytotoxicity in vitro characterization.
Autorzy
Rok wydania
2011
Czasopismo
Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
Numer woluminu
79
Strony
497-501
DOI
10.1016/j.saa.2011.03.019
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Novel platinum(IV) coordination compounds with 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one (HmtpO): cis–trans-[PtCl2(OH)2(NH3)(HmtpO)] (1), cis–trans-[PtCl5(HmtpO)][(CH3)2NH2] (2) have been prepared and structurally characterized by spectroscopic methods (1H, IR and X-ray crystallography (2)). The X-ray results indicate that the local geometry around the platinum(IV) centre approximates a typical octahedral arrangement with nitrogen atom N3 of the HmtpO and three chloride atoms in equatorial positions. The remaining two axial positions are occupied by two chlorides. The preliminary assessment of antitumor properties of (1) was performed as an in vitroantiproliferative activity against HL-60 human acute promyelocytic leukemia and HCV29T bladder cancer. The cis–trans-[PtCl2(OH)2(NH3)(HmtpO)] (1) exhibits higher cytotoxic activity against HL-60 (IC50 = 6.4 μM) than cisplatin.
Słowa kluczowe
Platinum(IV) complex, 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one, NMR, X-ray structure, Cytotoxicity
Adres publiczny
http://dx.doi.org/10.1016/j.saa.2011.03.019
Strona internetowa wydawcy
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