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Specific binding of Cu2+ and Ni2+ ions by thioamide analogs of tetraalanine.
Autorzy
Rok wydania
1997
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
66
Strony
45-49
DOI
10.1016/S0162-0134(96)00158-4
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Thioamide derivatives of short peptides are much more efficient ligands for Cu2+ and Ni2+ ions than their parent analogs. The most effective is the insertion of the thiocarbonyl group into the first, second, or third peptide linkage. In all of these cases, the sulfur atom is involved directly in metal ion binding, leading to the formation of very stable complexes. In all cases discussed, sulfur binding does not prevent an amide nitrogen deprotonation and its coordination to metal ion in basic solutions, although at the region close to physiological pH, sulfur is the basic donor for both Cu2+ and Ni2+ ions.
Adres publiczny
https://doi.org/10.1016/S0162-0134(96)00158-4
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