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Inne
Specific binding of Zn2+, Cd2+ and Ni2+ions by a cyclic four-cysteinyl peptide.
Autorzy
Rok wydania
2014
Czasopismo
Numer woluminu
43
Strony
16207-16212
DOI
10.1039/c4dt01614a
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The metal binding abilities of the GCASCDNCRACKK cyclic peptide towards Zn2+, Cd2+ and Ni2+ ions were studied by potentiometric and spectroscopic methods. The aim of this work was to understand the impact of cyclization on the peptide binding mode and the stability of the formed metal complexes when compared to its linear Ac-GCASCDNCRACKK-NH2 analogue. The obtained results clearly indicate that in the case of Cd2+ and Ni2+ complexes, the cyclization of the coordinating peptide distinctly increases the complex stability in the whole pH range studied. Surprisingly, different results were obtained for Zn2+ complexes. The peptide cyclization seems to prevent the binding of all four available cysteinyl residues to the Zn2+ ion, resulting in the reduced stability of the respective complexes.
Adres publiczny
http://dx.doi.org/10.1039/c4dt01614a
Strona internetowa wydawcy
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