Repozytorium
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Inne
Conversion of esters to thioesters under mild conditions.
Autorzy
Rok wydania
2021
Czasopismo
Organic and Biomolecular Chemistry
Numer woluminu
19
Strony
2991-2996
DOI
10.1039/d1ob00187f
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
We report conversion of esters to thioesters via selective C-O bond cleavage/weak C-S bond formation under transition-metal-free conditions. The method is notable for a general and practical transition-metal-free system, broad substrate scope and excellent functional group tolerance. The strategy was successfully deployed in late-stage thioesterification, site-selective cross-coupling/thioesterification/decarbonylation and easy-to-handle gram scale thioesterification. Selectivity and computational studies were performed to gain insight into the formation of weak C-S bonds by C-O bond cleavage, which contrasts with the traditional trend of nucleophilic additions to carboxylic acid derivatives.
Adres publiczny
http://dx.doi.org/10.1039/d1ob00187f
Strona internetowa wydawcy
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