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Inne
Structure and dynamics of the lincomycin-copper(II) complex in water solution by 1H and 13C NMR studies.
Autorzy
Rok wydania
2002
Czasopismo
Numer woluminu
41
Strony
1518-1522
DOI
10.1021/ic010388e
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The copper(II) complex of lincomycin in water solution at pH = 7.15 was characterized by 1H and 13C NMR and UV−vis spectroscopy. A 1:1 complex is formed in these conditions. The temperature dependence of spin−lattice relaxation rates was measured, showing that all protons behave in a similar fashion and slow exchange conditions prevail. The spin−lattice relaxation rate enhancements were interpreted by the Solomon−Bloembergen−Morgan theory. Reorientational dynamics of the complex was approximated by evaluating the motional correlation time of free lincomycin in water solution. The observed proton and carbon relaxation rate enhancements allowed us to calculate copper−proton and copper−carbon distances that were used for building a molecular model of the complex. The obtained data provide an interpretation of the relatively high stability constant.
Adres publiczny
https://doi.org/10.1021/ic010388e
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