Wydział Chemii

Inna Székács

Paweł Tokarz

Robert Horvath

Krisztina Kovács

Adam Kubas

Mari Shimura

Justyna Brasuń

Vadim Murzin

Wolfgang Caliebe

Zbigniew Szewczuk

Aneta Paluch

László Wojnárovits

Tünde Tóth

József Sándor Pap

Łukasz Szyrwiel

2019

Chemico-Biological Interactions

306

78-88

10.1016/j.cbi.2019.04.003

Naukowa

Angielski

Artykuł

SALEN- and SALAN-based complexes with catalytically active metal centers are very promising small molecules to be utilized as part of antioxidant therapies. Here we discuss a modified SALAN-type molecule armed with two phosphonate groups that significantly increase its water solubility and aid to furnish mono- or dinuclear complexes with Cu²⁺ ions. The regulation of the SOD-mimicking (i.e., catalytic) disproportionation reaction of the superoxide radical anion (O₂^•−) at pH ~7.5 could be achieved by adjusting the metal-to-ligand stoichiometry as confirmed by McCord-Fridovich and pulse radiolysis tests. The higher antioxidant activity of the dicopper complex can be explained by the better access of O₂^•− to the copper centers and their more positive Cu(II)/Cu(I) redox potential. Simultaneously the analysis of in vitro effect on cells morphology indicates that cytotoxicity is also affected by the metal-to-ligand ratio, however, the active complex molecules do not show notable cytotoxicity that, together with the observed SOD-like activities, makes them potential candidates for antioxidant therapies.

Cu-complex, SALAN, Antioxidant, SOD-Like activity, In vitro cytotoxicity

http://dx.doi.org/10.1016/j.cbi.2019.04.003

http://www.elsevier.com