Repozytorium
Wyszukaj
Kolekcje
Inne
Production and Characterization of Semi-Solid Formulations for the Delivery of the Cosmetic Peptide Palmitoyl-GHK
Autorzy
Rok wydania
2025
Czasopismo
Numer woluminu
12
Strony
50/1-50/16
DOI
10.3390/cosmetics12020050
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
In this study, vesicular lipid systems and semi-solid formulations for the skin application of Palmitoyl-GHK were formulated and characterized. Palmitoyl-GHK is a cosmetic peptide with anti-aging action, capable of treating the signs of skin aging by mainly stimulating collagen synthesis in the dermis. The so-called “ethosomes” were evaluated as nanovesicular systems constituted of phosphatidylcholine, organized in vesicles, ethanol, and water. In addition, semi-solid systems were produced and characterized, namely an organogel based on phosphatidylcholine, isopropyl palmitate, and water, a gel based on Poloxamer 407, and the poloxamer organogel, created by combining organogel and Poloxamer gel. To make the ethosomal dispersions suitable for skin application, xanthan gum was added as a gelling agent. Studies were therefore carried out on semi-solid formulations to determine (i) the spreadability, a key factor that influences various aspects of a topical/transdermal formulation, (ii) the occlusive factor, important to guarantee good effectiveness of a dermocosmetic product, and finally, (iii) the hydrating power, to study the effect of a formulation applied to the skin. A formulation study enabled the selection of the most suitable formulations for the incorporation of the active ingredient of interest. Palmitoyl-GHK was found to be soluble both in ethosomes and in the poloxamer organogel. In vitro studies were therefore conducted to evaluate the release kinetics of Palmitoyl-GHK from the formulations, via Franz cells. The qualitative–quantitative analysis, through analytical HPLC, highlighted that the active ingredient is released more slowly from semi-solid formulations compared to vesicular systems; in particular, the presence of poloxamer allows a controlled release of the peptide. Further studies will be necessary to verify the anti-aging efficacy of formulations containing the peptide.
Słowa kluczowe
peptide, anti-aging effect, ethosome gel, phosphatidylcholine, poloxamer organogel
Licencja otwartego dostępu
Licencja na prawach której można swobodnie kopiować, rozprowadzać, zmieniać i remiksować objęty prawem autorskim utwór (Utwór-przedmiot prawa autorskiego) pod warunkiem podania imienia i nazwiska autora utworu pierwotnego oraz źródła pochodzenia utworu.
Pełny tekst licencji: https://creativecommons.org/licenses/by/3.0/pl/legalcode
Adres publiczny
http://dx.doi.org/10.3390/cosmetics12020050
Strona internetowa wydawcy
Podobne publikacje
Targeted hybrid nanocarriers as a system enhancing the skin structure.
Lewińska Agnieszka, Domżał-Kędzia Marta, Kierul Kinga, Bochynek Michał, Pannert Dominika, Nowaczyk Piotr, Łukaszewicz Marcin
Insights into high hydrostatic pressure pre-treatment generating a more efficient catalytic mode of maltogenic α-amylase: Effect of multi-level structure on retrogradation properties of maize starch
Liu Zhenyu, Zhong Yuyue, Khakimov Bekzod, Fu Yongxia, Czaja Tomasz Paweł, Kirkensgaard Jacob Judas Kain, Blennow Andreas, Shen Qun, Engelsen Søren Balling
Copper(I) (pseudo)halide complexes with neocuproine and aminomethylphosphines derived from morpholine and thiomorpholine -in vitro cytotoxic and antimicrobial activity and the interactions with DNA and serum albumins.
Starosta Radosław, Bykowska Aleksandra, Kyzioł Agnieszka, Płotek Michał, Florek Magdalena, Król Jarosław, Jeżowska-Bojczuk Małgorzata