Wydział Chemii

Agnieszka Lewińska

Marta Domżał-Kędzia

Kinga Kierul

Michał Bochynek

Dominika Pannert

Piotr Nowaczyk

Marcin Łukaszewicz

2021

Molecules

26

1063/1-1063/20

10.3390/molecules26041063

Naukowa

Angielski

Artykuł

The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The analysis showed that nanoemulsion has a spherical morphology and size 220–300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130–260 nm). Additionally, we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, respectively. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, additionally consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions.

surfactin, levan, nanoemulsion, nanoparticles, skin, formulation, anti-aging

CC-BY

http://dx.doi.org/10.3390/molecules26041063

http://www.mdpi.com/journal/metals