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Inne
Organotin mefenamic complexes - preparations, spectroscopic studies and crystal structure of a triphenyltin ester of mefenamic acid: novel antituberculosis agents.
Autorzy
Rok wydania
2002
Czasopismo
Applied Organometallic Chemistry
Numer woluminu
16
Strony
360-368
DOI
10.1002/aoc.308
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The triphenyltin adduct of mefenamic acid, [SnPh3L] (1), the monophenyltin complex [PhSnOL] n (2), and the dibutyltin complex [SnBu2L2] (3), where HL is 2-[bis(2,3-dimethylphenyl)amino]benzoic acid (mefenamic acid), have been prepared and structurally characterized by means of vibrational, 1H and 13C NMR spectroscopies. The crystal structure of 1 has been determined by X-ray crystallography. X-ray analysis revealed a pseudo-pentacoordinated structure containing Ph3Sn coordinated to the carboxylato group. The structural distortion is a displacement from the tetrahedron toward the trigonal bipyramid. Significant CH–π interactions and intramolecular hydrogen bonds stabilize the structure 1. The polar imino hydrogen atom participates in intramolecular hydrogen bonds. Complex 1 is self-assembled via CH–π and stacking interactions. Vibrational and NMR data are discussed in terms of the crystal structure and the proposed structures for 1–3. Compounds 1 and 3 were tested for antimycobacterial activity against Mycobacterium tuberculosis H37Rv.
Adres publiczny
https://doi.org/10.1002/aoc.308
Strona internetowa wydawcy
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