Wydział Chemii

Monika K. Lesiów

Katarzyna Krupa

Urszula K. Komarnicka

Paulina K. Walencik

2018

Wiadomości Chemiczne

72

585-596

Naukowa

Polski

Artykuł

Fusobacterium nucleatum is a Gram-negative, anaerobic bacterium located in an oral cavity. This bacterium can migrate with blood to the different part of the human body e.g colon. The studies suggest participation of Fn in a colorectal cancer promotion, but a particular mechanism of this disease is still unclear. Colorectal cancer leads to million of new death cases each year. It is third in the worldwide in terms of mortality. The predictions for the coming years are not optimistic. The statistics encourage researchers to know the details of the mechanism of colorectal cancer. It is suggest, that outer membrane proteins of Fn are responsible for development of this disease. Transition metal ions such as Cu(I), Cu(II), Fe(II) can coordinate to proteins and generate free radicals by Fenton reaction. Reactive oxygen species (ROS) destroy important biological macromolecules such as DNA, proteins or lipids and cause different diseases. The paper presents characteristics of Fn and its outer membrane proteins, description of copper(II) complexes and their ability to ROS generation.

Fusobacteriumnucleatum, outer membrane proteins, copper(II) complexes, reactive oxygen species

Fusobacterium nucleatum, białka błony zewnętrznej, kompleksy miedzi(II), reaktywne formy tlenu

OTHER

https://www.dbc.wroc.pl/dlibra/publication/66676/edition/45212