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Inne
Mononuclear copper(II) nitrato complexes with methyl-substituted 4-nitropyridine N-oxide : physicochemical and cytotoxic characteristics.
Autorzy
Rok wydania
2010
Czasopismo
Journal of Inorganic Biochemistry
Numer woluminu
104
Strony
153-160
DOI
10.1016/j.jinorgbio.2009.10.016
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Three new complexes, products of the interaction of Cu(NO3)2 and methyl-substituted 4-nitropyridine N-oxides were synthesized and characterized by elemental analysis, magnetic, spectroscopic (IR, FIR and EPR), thermal and X-ray methods. The complexes (magnetic moments 1.70–1.81 BM at 300 K) of general formula [Cu(H2O)(NO3)2L2], L = 2-methyl-4-nitropyridine N-oxide and [Cu(NO3)2 L′2], where L′ = 2,6-dimethyl- and 2,3,6-trimethyl-4-nitropyridine N-oxide were obtained. The compounds were unstable upon dissolution. The X-ray single crystal structure of Cu(II) complex with 2,6-dimethyl-4-nitropyridine N-oxide was determined and analysed. The compounds and free ligands were tested in vitro on the cytotoxic activity against MCF-7 and SW-707 human cancer cell lines. The complexes with 4-nitropyridine N-oxide (a reference) and 2-methyl-4-nitropyridine N-oxide show a significant anti-proliferative activity against studied cell lines. A reciprocal relationship between the activity and the number of methyl groups was observed. Both ligands and complexes are cytotoxic active but to the different cell lines.
Słowa kluczowe
Copper complexes, Methyl-substituted 4-nitropyridine N-oxide, crystal structure, infrared spectra, EPR spectra, magnetic moments, cytotoxicity, Thermal decomposition
Adres publiczny
https://doi.org/10.1016/j.jinorgbio.2009.10.016
Strona internetowa wydawcy
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