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Inne
Structure-activity relationship disturbed by a solvolytic process: study on the [Cu(II)-4-nitropyridine N-oxide derivative] system.
Autorzy
Rok wydania
2013
Czasopismo
Numer woluminu
50
Strony
146-153
DOI
10.1016/j.poly.2012.09.060
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The chelate complex [CuCl2(L)] where L = 2-methylamino-3-methyl-4-nitropyridine-N-oxide has been obtained and characterized, both physicochemically (by the X-ray structure analysis of the complex and the ligand, FTIR, EPR and electronic spectroscopy, and thermal analysis) and cytotoxically (MCF-7, A549, SW707, P388, Balb3T3). In solution, atypically for chelate complexes, it undergoes rapid solvolysis forming various 6- (or 5) and 4-coordinate species, depending upon the solvent. Such rapid decomposition may indicate a catalytic effect of the copper operating in the system. However, the cytotoxic activity in solution for the new copper chelate complex appeared to be a surprisingly low. Thus, before drawing any conclusions on the structure–activity relationship, one must carefully check the chemical identity of the compound(s) in both phases.
Słowa kluczowe
Copper(II) complexes, 4-Nitropyridine-N-oxide derivative, Crystal structure, Solvolisis
Adres publiczny
http://dx.doi.org/10.1016/j.poly.2012.09.060
Strona internetowa wydawcy
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