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Impact of aluminium ions on adriamycin-type ligands.
Autorzy
Rok wydania
1993
Czasopismo
Journal of the Chemical Society, Dalton Transactions
Strony
455-459
DOI
10.1039/DT9930000455
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Potentiometric and spectroscopic measurements have shown that Al3+ ions form 1:1 complexes with adriamycin and its analogues. The major complex at pH > 5 is a tetrahedral species in which the metal ion is co-ordinated to the ligand via two anthracycline oxygens. Two OH– groups complete the co-ordination sphere. Although the complexes are comparatively stable the formation of [Al(OH)4]– at pH > 8.5 excludes adriamycin from the metal ion co-ordination sites. The unusual fluorometric behaviour of the drug molecule is also present in the complex formed at lower pH.
Adres publiczny
https://doi.org/10.1039/DT9930000455
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