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Copper(II) binding to tobramycin: potentiometric and spectroscopic studies.
Autorzy
Rok wydania
1998
Czasopismo
Numer woluminu
313
Strony
265-269
DOI
10.1016/s0008-6215(98)00288-2
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Protonation and Cu(II) binding by tobramycin, an aminoglycosidic antibiotic, was studied by potentiometry and UV-vis, CD and EPR spectroscopies. A range of mononuclear complexes of a general formula CuHnL was found, with n between 3 and -2. Tobramycin anchors Cu(II) with an ¿NH2, O-¿ chelate of the C-ring of its molecule. The amino and hydroxyl groups of the A-ring of tobramycin also participate in the binding at pH 7 and higher. The resulting structure involves both terminal aminosugar rings but eliminates the donors of the central streptamine unit from the coordination. A comparison between tobramycin and its close analog, kanamycin B [M. Jezowska-Bojczuk, W. Bal and H. Kozłowski, Inorg. Chim. Acta, 275-276 (1998) 541-545] reveals the importance of the A3-OH group for the binding properties of these aminoglycosides.
Adres publiczny
https://doi.org/10.1016/s0008-6215(98)00288-2
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