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Inne
Kanamycin revisited: a combined potentiometric and spectroscopic study of copper(II) binding to kanamycin B.
Autorzy
Rok wydania
1998
Czasopismo
Numer woluminu
275-276
Strony
541-545
DOI
10.1016/S0020-1693(97)06113-6
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Coordination of Cu(II) to kanamycin B, an aminoglycosidic antibiotic, was studied by potentiometry and UV-Vis, circular dichroism and electron paramagnetic resonance spectroscopies. Mononuclear complexes with stoichiometries ranging from CuH3A to CuH−2A were found. Kanamycin B binds Cu(II) through nitrogen and oxygen donors of two terminal aminosugar rings, but the central deoxystreptamine moiety does not participate in the binding. The complex mediates oxidation of 2′-deoxyguanosine by H2O2 very effectively. These properties may contribute to biological properties of kanamycin B.
Słowa kluczowe
Aminoglycosidic antibiotic, Kanamycin complexes, Copper complexes
Adres publiczny
https://doi.org/10.1016/S0020-1693(97)06113-6
Strona internetowa wydawcy
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