Wydział Chemii

Patrycja Piękoś

Irena Helena Maliszewska

Nurgul Tursynova

Jerzy Sokolnicki

Maria Jerzykiewicz

Stanisław Bartkiewicz

Aleksander Filarowski

2024

Journal of Molecular Liquids

413

126008/1-126008/10

10.1016/j.molliq.2024.126008

Naukowa

Angielski

Artykuł

This paper focuses on solvatochromic studies of a new synthesised BODIPY dye with piperonal and ortho-hydroxy aryl Schiff base substituents (BD-2-Schiff). The studied dye has been analysed by spectroscopic and computational techniques to have a deep insight into the impact of the solvents’ polarity and the specific interactions on the dye characteristics. The synthesized dye turns to be sensitive to external specific interactions, caused by protic solvents and acid, which change spectral characteristics of BODIPY-2-Schiff. The calculations by the density functional theory (DFT) and the time-dependent density functional theory (TD-DFT) have been accomplished for the interpretation of the obtained experimental results. The synthesized dye has been evaluated as a photosensitizer for the light induced inactivation of Staphylococcus aureus (S. aureus) and Acinetobacter baumannii (A. baumannii). The synthesized BODIPY dye has shown a significant photocidal activity (above 90 %) against these pathogenic bacteria at low microgram concentrations and excitation with low doses of visible light (0.72 J/cm²; λ = 519 nm).

BODIPY, Schiff, Solvatochromism, pH, TD-DFT, S.aureus, A.baumannii

CC-BY

http://dx.doi.org/10.1016/j.molliq.2024.126008

http://www.elsevier.com