Wydział Chemii

Nurgul Tursynova

Irena Helena Maliszewska

Kinga Jóźwiak

Jerzy Sokolnicki

Andrzej Kochel

Paweł Lipkowski

Stanisław Bartkiewicz

Aleksander Filarowski

2024

Journal of Photochemistry and Photobiology A-Chemistry

450

115474/1-115474/9

10.1016/j.jphotochem.2024.115474

Naukowa

Angielski

Artykuł

The paper focuses on the synthesis of the chloro-, methyl and carbonyl derivatives of Benzodioxole-BODIPY dye (BODIPY – 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene). Three BODIPY dyes have been synthesized and characterized by biological, spectroscopic, crystallographic and computational methods. The influence of the electron donating and electron withdrawing properties of the substituents on the position of the absorption and emission bands have been analysed. The synthesized compounds have been evaluated as photosensitizers for the photodynamic inactivation of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The dyes revealed a significant photocidal activity against these pathogenic bacteria at low micromolar concentrations. The photo-toxic results showed that the synthesized dyes impact more affectively on S. aureus (Gram-positive bacteria) compared to Escherichia coli (Gram-negative bacteria).

BODIPY dye, S. aureus, E. coli, Photoinactivation, TD-DFT

http://dx.doi.org/10.1016/j.jphotochem.2024.115474

http://www.elsevier.com