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Distribution in rats internal organs of intraperitoneally given 125I-labeled heptapeptide [2-8]-leucopyrokinin ([2-8]-LPK), a truncated analog of insect neuropeptide leucopyrokinin.
Autorzy
Rok wydania
2015
Czasopismo
Advances in Clinical and Experimental Medicine
Numer woluminu
24
Strony
579-584
DOI
10.17219/acem/24503
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Background. It was previously found that synthetic, insect-derived octapeptide leucopyrokinin (LPK) applied directly into the lateral brain ventricle induced a significant antinociceptive effect in rats. Its synthetic truncated analog heptapeptide [2-8]-leucopyrokinin displayed a stronger antinociceptive effect in comparison to native LPK. Moreover it was previously found a high accumulation of these both 125I-labeled peptides in adrenals, as well as in hypothalamus and in hippocampus of rats brain.
Objectives. The aim of the present study was to assess the distribution of 125I-labeled [2-8]-leucopyrokinin in rats’ internal organs an in several parts of the brain after peripheral – intraperitoneal (i.p.) administration.
Material and Methods. The study was performed on male Wistar rats. A synthetic [2-8]-leucopyrokinin ([2-8]-LPK) was iodinated with Na125I. On the day of experiment a solution of 125I-[2-8]-LPK was i.p. injected and the next after 1 and 24 h animals were sacrificed by decapitation. Radioactivity levels in samples of parts of the brain and of internal organs were determined by counter Gamma Auto Count.
Results. A uniform, low accumulation 125I-[2-8]-LPK was found in evaluated samples of the brain and in internal organs.
Conclusion. The results of the present study indicate a weak penetration into the brain and internal organs of intraperitoneally applied 125I-[2-8]-LPK in rats and correspond with previously determined weak biological effects of i.p. injected LPK and [2-8]-LPK.
Słowa kluczowe
[2-8]-leucopyrokinin, distribution in rat brain and internal organs, intraperitoneal administration
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Pełny tekst licencji: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
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