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Heteronuclear and homonuclear Cu2+ and Zn2+ complexes with multihistidine peptides based on zebrafish prion-like protein.
Autorzy
Rok wydania
2009
Czasopismo
Numer woluminu
48
Strony
7330-7340
DOI
10.1021/ic9008202
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The homeostasis of metal ions, especially copper and zinc, is a major factor that may influence the prion diseases and the biological function of prion protein (PrP). The His-rich regions are basic sites for metal binding and antioxidant activity of the PrP structures. Animal prion-like proteins contain also His-rich domains, and their coordination chemistry may provide better insight into the chemistry and biology of PrP structures and related diseases. Herein, we report an equilibrium study on heteronuclear Zn2+−Cu2+ complexes with zrel-PrP fragments from zebrafish. Potentiometric, spectroscopic, and mass spectrometric methods showed that the binding of copper is much more effective than the binding of zinc. At physiological pH, both metals bind to the histidine imidazole N donors of the studied peptides.
Adres publiczny
https://doi.org/10.1021/ic9008202
Strona internetowa wydawcy
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