Repozytorium
Wyszukaj
Kolekcje
Inne
The Cu2+binding properties of branched peptides based on L-2,3-diaminopropionic acid.
Autorzy
Rok wydania
2014
Czasopismo
Numer woluminu
53
Strony
7951-7959
DOI
10.1021/ic5007428
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
Three new branched peptides, namely, H-Gly-Dap(H-Gly)-Gly-NH2 (3G), H-His-Dap(H-His)-Gly-NH2 (2HG), and H-Gly-Dap(H-Gly)-His-NH2 (2GH), where Dap stands for the 2,3-diaminopropionic acid residue, were synthesized by solid phase procedures. Because of the junction at Dap these peptides have three available pending arms for metal chelation. The complex formation between these peptides and 1 equiv of Cu2+ was investigated as a function of pH by potentiometry ultraviolet–visible absorption, circular dichroism, and X-band electron paramagnetic resonance spectroscopy in aqueous medium. Our results clearly demonstrate that cooperation between all three peptide arms essentially contributes to the stability of copper(II) complexes.
Adres publiczny
http://dx.doi.org/10.1021/ic5007428
Strona internetowa wydawcy
Podobne publikacje
Heteronuclear and homonuclear Cu2+ and Zn2+ complexes with multihistidine peptides based on zebrafish prion-like protein.
Valensin Daniela, Szyrwiel Łukasz, Camponeschi Francesca, Rowińska-Żyrek Magdalena, Molteni E., Jankowska Elżbieta, Szymańska Aneta, Gaggelli Elena, Valensin Gianni, Kozłowski Henryk
Binding of Ni2+ and Cu2+ ions peptides with a Cys-His motif.
Kulon Kinga, Valensin Daniela, Kamysz Wojciech, Nadolny R., Gaggelli Elena, Valensin Gianni, Kozłowski Henryk
Structural characterization of Cu2+, Ni2+ and Zn2+ binding sites of model peptides associated with neurodegenerative diseases.
Migliorini Caterina, Porciatti Elena, Łuczkowski Marek, Valensin Daniela