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Crystal structure, ferromagnetic coupling and antibacterial activity of a new family of dicopper(II) complexes supported by auxiliary para-substituted benzoate linkers
Autorzy
Rok wydania
2024
Czasopismo
Journal of Molecular Structure
Numer woluminu
1318
Strony
139423/1-139423/20
DOI
10.1016/j.molstruc.2024.139423
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
In work to investigate the biologically active transition metal complexes, a new family of ferromagnetically coupled dicopper(II) complexes (1–3) were synthesized and structurally characterized. Structural analyses of the complexes revealed that the copper centers in 1–3 are doubly bridged by one alkoxide group of the organic scaffold, H3cpdp (H3cpdp = N,N'-bis[2-carboxybenzomethyl]-N,N'-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol), and one auxiliary para-chlorobenzoate/para-nitrobenzoate/para-methylbenzoate linker. Variable-temperature magnetic susceptibility data disclosed the occurrence of predominant ferromagnetic coupling within the doubly bridged dicopper(II) cores with J values of +31.3(1), +29.1(1) and +35.6(1) cm−1 for 1, 2 and 3, respectively. All three complexes were studied for antibacterial activity against the two strains of Pseudomonas aeruginosa (PaO1 and Pa27853). The studies revealed an excellent antibacterial activity with minimum inhibitory concentration (MIC) values falling in the range of 300–700 μg/mL with 95 % confidence interval. Our experimental results revealed that 1–3 are far superior antibacterial agents compared to bare H3cpdp and CuCl2. Complexes 1–3 showed ability to cause lipid peroxidation that disrupts the bacterial cell membrane and causes the leakage of cytoplasmic contents such as DNA and protein as a consequence of accumulation of intracellular reactive oxygen species (ROS) leading to bacterial cell death. The experiment with human embryonic kidney (HeK293) cell line exposure to 1–3 indicated a lack of measurable cytotoxicity at their MIC values. However, a comparative assessment of their biological efficacies specified that the antibacterial activity of 2 is considerably higher than that of 1 and 3.
Słowa kluczowe
Dicopper(II) complex, Crystal structure, Thermal property, Ferromagnetic interaction, Antibacterial activity, Pseudomonas aeruginosa
Adres publiczny
http://dx.doi.org/10.1016/j.molstruc.2024.139423
Strona internetowa wydawcy
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