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Silver(I) Coordination Polymers: From Mechanosynthesis and Structural Features to Bioactivity
Autorzy
Rok wydania
2026
Czasopismo
Strony
1-11
DOI
10.1021/acs.cgd.6c00023
Kolekcja
Język
Angielski
Typ publikacji
Artykuł
The design of bioactive coordination polymers represents an important research direction in crystal engineering and materials chemistry for combatting antimicrobial resistance. In this study, two new silver(I) coordination polymers (CPs), [Ag2(PTA=S)2(tpa)]n·nH2O (1) and [Ag2(PTA=S)2(Hcda)2]n·nH2O (2), were assembled from 1,3,5-triaza-7-phosphaadamantane-7-sulfide (PTA=S) and two types of carboxylic acid linkers, namely terephthalic (H2tpa) or 1,4-cyclohexanedicarboxylic (H2cda) acids. The syntheses were conducted via mechanochemical approach known as liquid-assisted grinding (LAG) or via solution self-assembly. The compounds were isolated as crystalline solids with distinct 3D (1) or 1D (2) coordination polymer structures constructed from the 1D {Ag2(μ3-PTA=S)2}2+ chain motifs. The crystal structures of 1 and 2 feature the fsx/I and SP 1-periodic net (6,3)(0,2) topologies, respectively. Antimicrobial assays demonstrate the antimicrobial potential of 1 toward HAdV-C5 (human adenovirus type 5) and HSV-1 (herpes simplex virus type 1) with virus titer reduction values of 3 log; (99.9%) and 3.5 log (99.95%), respectively. Both compounds 1 and 2 also inhibit the growth of Gram-positive (S. aureus) and Gram-negative (E. coli, P. aeruginosa) bacteria and yeast with the MIC values in the range of 20–50 μg mL–1. In addition, 1 and 2 exhibit remarkable antiproliferative activity on A549 (human lung cancer) and LM-MEL-75 (human melanoma) cells (EC50 of 1 μM/mL and 9.45 μM/mL, respectively) with lower cytotoxicity of 1 (EC50 > 100 μM/mL) to normal human dermal fibroblast (NHDF) cells. This study widens the family of bioactive CPs with highly promising antimicrobial and antiproliferative behavior.
Słowa kluczowe
Toxicity, Cells, Ligands, Antimicrobial agents, Silver
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Pełny tekst licencji: https://creativecommons.org/licenses/by/3.0/pl/legalcode
Adres publiczny
http://dx.doi.org/10.1021/acs.cgd.6c00023
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